KNT-127 is a selective, blood-brain barrier-penetrant δ-opioid receptor (DOR) agonist used in preclinical neuroscience research. It displays high affinity for DOR (Ki = 0.16 nM), biased signaling toward cAMP over β-arrestin pathways, and has been reported to increase dopamine and L-glutamate release in key brain regions. For research use only.
- Selective δ-opioid receptor agonist with high DOR potency.
- Biased ligand favoring cAMP signaling over β-arrestin recruitment.
- Blood-brain barrier penetrant, suitable for central nervous system studies.
- High chemical purity (99.6%) and off-white to light yellow solid form.
- Available in small solid quantities and DMSO solution formats for in vitro and in vivo work.